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Terpene: Caryophyllene

Caryophyllene is a spicy terpene that has a wide range of aromatic notes; such as Citrus, Earthy, Pepper, and Spice.

This Terpene is also a primary terpene.

Top Plants Found In:

Bidens Pilosa-730,000ppm


Black Pepper-352,000ppm

Beef Steakmint-167,000


Top Cannabis Strains Found In:


Bubba Kush

Sour Diesel



“Regulates pain sensations, Anti-inflammatory. The only terpene known to act on the endocannabinoid system, which regulates a variety of physiological processes.”

A study concluded in 2019 found:

“βCaryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn’t psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1). Among the various biological activities, BCP exerts anti-inflammatory action via inhibiting the main inflammatory mediators”

A Caryophyllene’s toxicology report concluded that:

“The no observed adverse effect level was the highest dosage level administered of 700 mg/kg body weight/d for both male and female rats. The study was conducted as part of an investigation to examine the safety of BCP oil for its proposed use in medical food products.”

Something unique about Carophylene:

Caryophyllene is a bigger molecule than terpenes like myrcene and limonene. Caryophyllene’s molecular structure also contains a cyclobutane ring, something rare in nature and not found in any other known cannabis terpene.